Hallo liebe Wissenden,
kann mir bitte jemand etwas zu der These sagen, dass die gleichzeitige Einnahme von Magnesium & Kalzium die Aufnahme von Kalzium behindert?
Am liebsten wäre mir ein guter Link oder der Hinweis auf eine bestimmte Studie…
Im Archiv bin ich bislang lediglich auf diesen Artikel gestoßen:
/t/magnesium-calcium–2/2437336
Vielen Dank für Eure Hilfe
und liebe Grüße
von
Stefanie
Hallo!
kann mir bitte jemand etwas zu der These sagen, dass die
gleichzeitige Einnahme von Magnesium & Kalzium die Aufnahme
von Kalzium behindert?
Das scheint zu stimmen. Wie relevant das bei den einzelnen Konzentrationen ist, das müsste man mal ausrechnen.
Am liebsten wäre mir ein guter Link oder der Hinweis auf eine
bestimmte Studie…
Ja, hier sind ein paar Texte. Leider sind das nicht gerade praktische Patientenstudien 
Schau halt, was Du davon lesen magst und stell Fragen bei Interesse. Der erste Link ist sehr ausführlich und beantwortet die Frage vermutlich. Die anderen zitierten Abstracts hab ich halt auch noch gefunden.
Viele Grüße, Stefan
J Physiol. 1972 Dec
Metal inhibitors of calcium uptake by the duodenum of the rat.
http://www.pubmedcentral.nih.gov/articlerender.fcgi?..
Weitere Texte hierzu:
" J Hypertens. 2001 Jan;19(1):161-2.
Effect of oral magnesium supplementation on blood pressure, platelet aggregation and calcium handling in deoxycorticosterone acetate induced hypertension in rats.
* Kh R,
* Khullar M,
* Kashyap M,
* Pandhi P,
* Uppal R.
Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
OBJECTIVE: To study the effect of oral magnesium supplementation on blood pressure, platelet aggregation and platelet calcium handling in deoxycorticosterone acetate (DOCA)-induced hypertension in rats. DESIGN AND METHODS: Rats were divided into four groups of 20 each. Drug treatments were given for a 6-week period. Control rats were vehicle treated. In the second group, DOCA, 15 mg/kg, was injected subcutaneously twice weekly with 1% NaCl used instead of drinking water. The third group was given magnesium oxide (MgO), 1 g/kg daily, orally by gavage. The fourth group was given MgO along with DOCA and 1% NaCl. Blood pressure and heart rate were measured weekly. Platelet aggregation, intracellular calcium, calcium uptake and calcium efflux studies were performed at the end of sixth week. Serum magnesium concentration, plasma levels of reactive nitrogen intermediates (RNI) and citrulline were also measured RESULTS: There was a significant rise in blood pressure in the DOCA-treated rats. Magnesium prevented the gradual rise in blood pressure when given along with DOCA, but had no effect in normotensive rats. Heart rate did not show any significant change. Platelet aggregation was significantly reduced in all the treatment groups compared to the control group. DOCA treatment produced a significant increase in the intracellular calcium concentration as well as the calcium uptake compared to the control group. Magnesium supplementation inhibited the increased intracellular calcium concentration and calcium uptake in DOCA-treated rats. RNI and citrulline levels were elevated in all the treatment groups. Serum magnesium levels were significantly higher in the magnesium-treated and DOCA plus magnesium-treated rats. CONCLUSIONS: Magnesium supplementation prevents blood pressure elevation in DOCA hypertensive rats. These effects are associated with inhibition of platelet calcium uptake and decreased intracellular free calcium concentration."
"J Am Coll Nutr. 1991 Feb;10(1):44-9. Links
The influence of zinc, magnesium, and iron on calcium uptake in brush border membrane vesicles.
* Roth-Bassell HA,
* Clydesdale FM.
Department of Food Science, University of Massachusetts, Amherst 01003.
The effects of adding increasing concentrations of magnesium (Mg), zinc (Zn), and iron (Fe) on calcium (Ca) uptake into rat brush border membrane vesicles was measured. At ratios of 1:1, based on the RDA, none of these minerals were found to significantly decrease calcium uptake. Mg, however, inhibited Ca uptake at an RDA ratio of 3:1 (Mg:Ca). At higher RDA ratios (Zn:Ca 10:1), Zn also decreased Ca uptake. In a comparison of the molar ratios of the above cations, Zn inhibited Ca uptake the most (0.12:1), possibly by competing directly at high-affinity Ca binding sites. Fe did not decrease Ca uptake but rather demonstrated an enhancing effect at high concentrations (20:1). When mixtures of the above divalent cations were studied, the effects on Ca uptake could largely be explained by the actions of the ions individually."
" Biol Met. 1989;2(1):36-9.
The effect of zinc and magnesium on calcium uptake into the rat duodenum slices.
* Witkowska D,
* Sedrowicz L,
* Oledzka R,
* Bialek A.
Department of Bromatology, Medical Academy of Warsaw, Poland.
The experiments were carried out on 80 male Wistar rats, divided into four groups as follows: group 1, treated orally with ZnCl2 at a dose of 10 mg Zn2+/kg for 14 days; group 2, control; group 3, MgCl2-treated at a dose of 5 mg Mg2+/kg; group 4, treated with ZnCl2 plus MgCl2 in the same manner as groups 1 and 3. The influx of calcium into the rat duodenum slices was investigated in vitro by the method of Papworth and Patrick. Over a range of calcium concentrations (0-10 mM) the influx of this element was defined as a sum of a saturable term (active transport) and a linear term dependent on concentration (passive transport). In the zinc-treated rats only the saturable term was affected. The study of this term by Lineweaver-Burk plots showed a decrease of the half-saturation constant, Kt, while the maximal value, Jm, remained unchanged. Moreover, magnesium was shown to interact with zinc at gut level because simultaneous oral administration of Mg2+ and Zn2+ to rats protected them against the inhibition of calcium uptake observed when Zn2+ was given alone."